|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The unexpected finding of a decreased frequency of HLA-DRB1*1601 in ulcerative colitis should be further investigated.
|
7835583 |
1995 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Data on perinuclear ANCA (pANCA) and HLA-DRB1 were available from 274 ulcerative colitis (UC) patients without known liver disease.
|
27558072 |
2017 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
DRB1*1502 or DRw11 have a probability of being closely related to the intractability of UC.
|
7942717 |
1994 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Genomic DNAs were obtained from a cohort of n = 383 subjects recruited as part of an Ulcerative Colitis study and analyzed for HLA-DRB1.
|
23555798 |
2013 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
These results extended the reported positive association of DRB1*1502 with UC to another population and supported the genetic susceptibility associated with HLA genes for disease development.
|
9777329 |
1998 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
HLA-DRB1*03 was less frequent in UC patients than in healthy controls (8% vs 28%, PC < 0.03).
|
9115580 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
No significant associations were found between any FCRL3 SNP and CD or UC, but the stratification in patients with UC by human leukocyte antigen (HLA) showed a significant increase in heterozygosity at the FCRL3 locus, especially -169 AG (AG vs AA+GG, P= 0.0027, odds ratio = 3.6, 95% confidence interval 1.4-2.9), when HLA-DRB1*0103 carrier patients were compared with HLA-DRB1*0103 noncarriers.
|
17389014 |
2007 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Results were as follows: 1) the presence of DQB1*0402 (RR=3.90, Pc=0.0001) was positively associated with CD; 2) the presence of DRB1*1502 (RR=4.51, P<1X10(-8)), DRB5*0102 (RR=4.70, Pc<1x10(-8)), DQA1*0103 (RR=3.72, Pc=1x10(-5)), DQB1*06011 (RR=3.78, PC=1x10(-5)), DPA1*0201 (RR=3.23, Pc=0.0001) and DPB1*0901 (RR=4.83, PC<1x10(8)) was positively associated and that of DRB4*0101 (RR=0.20, Pc<1X10(-8)) and DQA1*0302 (RR=0.34, Pc=0.001) negatively associated with UC; 3) haplotype analysis showed a positive association between the presence of DRB1*0410-DQA1*0302-DQB1*0402 and DRB1*0802-DQA1*0401-DQB1*0402 with CD, and a negative association between the presence of DRB1*1502-DQA1*0103-DQB1*06011 and CD, there was no association of DRB1*08032-DQA1*0103-DQB1*06011 with CD; and 4) in UC, a positive association with the presence of DRB1*1502-DQA1*0103-DQB1*06011 was found, but DRB1*08032-DQA1*0103-DQB1*06011 was not associated with it.
|
10323339 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
These data demonstrate the association of the HLA DRB1*0103 allele with both Crohn's disease and ulcerative colitis and with large intestine-restricted disease in non-Jewish IBD patients and therefore identify HLA DRB1*0103 as a potentially important contributor to disease susceptibility and to expression of colonic involvement in IBD.
|
12656131 |
2003 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The allele frequency of HLA-DRB1*09 was significantly higher in patients with UC diagnosed at the age of 40 years or older than in those with UC diagnosed before the age of 40 years (OR=2.31, Pc=0.022).
|
18416774 |
2008 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
A combination association map of Japanese UC using our current and previous studies showed two equal peaks of association on HLA-DRB1 and HLA-B, indicating the possible existence of two casual variants in the HLA region inside and outside the 400 kb block found in UK.
|
19493234 |
2009 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
HLA-B*52 and DRB1*1502 are reported to be strongly associated with UC in Japan.
|
15215890 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
DRB1*1502, which was previously shown to be dominant in Japanese patients with UC, was not observed in this case.
|
16437733 |
2005 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The allele HLA-DRB1*12 was more frequent in patients with ulcerative colitis (p = 0.01).
|
10190246 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
This appears to be true for both inflammatory bowel diseases as HLA-DRB1*0103 is associated both with colonic Crohn's disease and ulcerative colitis.
|
15626888 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Significant increase was observed in Bw52, DPw9 (DPB1*0901), and DR2 (DRB1*1502) in Japanese patients with UC.
|
8096500 |
1993 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective role of HLA-DRB1*04 against the disease in people of Kerman.
|
26546900 |
2015 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Integrative analysis of TWAS and messenger RNA (mRNA) expression data detected several tissues related common genes for UC, such as HLA-DRB1 (P<sub>TWAS</sub> = 0.024; mRNA expression ratio = 1.700) and TAP2 in colon (P <sub>TWAS</sub> = 0.047; mRNA expression ratio = 2.170).
|
31009124 |
2019 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Our data are consistent with those of Japanese studies in that DR2 and DRB1*1502 are positively associated with UC patients.
|
12073071 |
2002 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Our previously reported association of DR2 with UC was attributable to DRB1*1502 (OR = 2.6, p = 0.006).
|
10689124 |
2000 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Previously, we have reported that the DRB1*1502 and DRw11 genes were closely related to the intractability of UC.
|
11993515 |
2002 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10<sup>-6</sup>): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC.
|
27693347 |
2017 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
LHGDN |
The allele frequency of HLA-DRB1*09 was significantly higher in patients with UC diagnosed at the age of 40 years or older than in those with UC diagnosed before the age of 40 years (OR=2.31, Pc=0.022).
|
18416774 |
2008 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The allelic combination DRB1*0103/D6S273-5/BAT_2-8/TNFa11b4c1d3e3/IKBL+738(C)/MICA5.1 that includes the telomeric class III markers of the 7.1 ancestral haplotype is highly increased in patients with UC (P=0.0001, OR=10.57), especially in those with the extensive form of the disease (P=0.02, OR=3.41 extensive versus distal).
|
16116311 |
2005 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |